Physiology and Pathophysiology of Proteinase-Activated Receptors (PARs): PAR-2 as a Potential Therapeutic Target

PAR-2 is the second member of the family of proteinase-activated receptors activated by trypsin, tryptase, and several other serine proteinases.In order to evaluate the therapeutic Unitard potential for PAR-2, we have performed studies on PAR-2-mediated signal transduction and investigated the effects of PAR-2 gene deficiency in disease models.In a

read more

A sensitivity-based procedure to select representative fish species for the Marine Strategy Framework Directive indicator development, applied to the Greater North Sea

Harmonizing biodiversity assessments under the Marine Strategy Framework Directive (MSFD) at the pan-European level is a crucial task for the Regional Sea Conventions and EU Member States in the coming years, particularly for fish assessment in Descriptor 1 (biodiversity).Precondition for coherent fish assessments is the establishment of a regional

read more